A good trial of a serotonin-reuptake inhibitor (SSRI/SRI) usually improves OCD and body dysmorphic disorder (BDD) symptoms. But the medication may not help if you didn’t take a high enough dose, try it for long enough, or take it every day. Selective serotonin reuptake inhibitors (SSRIs) are the first-line medication treatment for both OCD and BDD. SSRIs available in the U.S. are fluoxetine (Prozac), sertraline (Zoloft), escitalopram (Lexapro), fluvoxamine (Luvox), and paroxetine (Paxil). Citalopram (Celexa), another SSRI, is not recommended because OCD and BDD often require relatively high SSRI doses, and the maximum dose of citalopram that can be used (the dosing limit is firmer than for other SSRIs) is often too low to effectively treat these disorders. Clomipramine (Anafranil) is an SRI (not an SSRI) that is also effective for OCD and BDD.
Effective SSRI doses for OCD and BDD are often higher than those used to treat depression and certain other mental health disorders. An SSRI/SRI should be tried for at least 12 weeks, reaching a high enough dose during that time and being sure to take the medication every day. If OCD and BDD don’t improve enough, it may help to take a dose that is higher than the manufacturer’s maximum dose (but this should not be done with clomipramine or citalopram).
If a good trial of an SSRI/SRI isn’t adequately helpful, OCD and BDD symptoms may improve by adding certain other medications to the SSRI/SRI. Alternatively, patients who do not improve sufficiently with one SSRI/SRI medication may improve with another one.
Patients with mild to moderate OCD or BDD should be treated with either medication (an SSRI/SRI) or therapy (CBT), or both medication and CBT, depending on patient preference, the presence or absence of associated psychiatric conditions, treatment availability, and other considerations. Severe OCD and severe BDD should be treated with both CBT and an SSRI/SRI concurrently.
Medication treatment is very similar for BDD and OCD. But CBT for these disorders has some important differences, so CBT needs to be tailored to each disorder.