Objective—To address the maternal and neonatal risks of both depression and antidepressant
exposure and develop algorithms for periconceptional and antenatal management.
Method—Representatives from the American Psychiatric Association, the American College of
Obstetricians and Gynecologists and a consulting developmental pediatrician collaborated to
review English language articles on fetal and neonatal outcomes associated with depression and
antidepressant treatment during childbearing. Articles were obtained from Medline searches and
bibliographies. Search keywords included pregnancy, pregnancy complications, pregnancy
outcomes, depressive disorder, depressive disorder/dt, abnormalities/drug-induced/epidemiology,
abnormalities/drug-induced/et. Iterative draft manuscripts were reviewed until consensus was
achieved.
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