The use of cannabis for medical indications has received considerable attention as several states have moved to legalize cannabis for various purposes. A growing number of patients cite post-traumatic stress disorder (PTSD) as the reason for seeking cannabis for medical purposes in states where it is legal.1 Furthermore, approximately 15% of Veterans who are treated in Department of Veterans Affairs (VA) outpatient PTSD clinics report recent (past 6 months) cannabis use.2 This position statement was developed through review of the evidence to date and to establish the APA's consensus on the matter.